A.I.VOGEL PREPARATYKA ORGANICZNA PDF

A. I. Vogel, Preparatyka organiczna (WNT Warszawa,), p. Zielińska J., Makowski M., Maj K., Liwo A., Chmurzyński L.() Anal. A.I. Vogel. Preparatyka Organiczna, WNT, Warszawa (), p. F.V. Lovecchio, E.S. Gore, D.H. Bush. J. Am. Chem. Soc., 96 (), p. Soc. (), p. A.I. Vogel. Preparatyka Organiczna W.N.T. Warszawa ( ), p. C.G. Hatchard, C.A. Parker. Proc. Roy. Soc., A (), p.

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Subsequently, the solution was diluted with dichloromethane 5 mLfiltered, and the filtrate was concentrated under reduced pressure.

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For example, in B cell malignancy, B cells of various stages of differentiation show unregulated proliferation. Short-acting pharmaceutical compositions i. Kim, Retrieved from the Internet on Apr. Viable bacteria are counted by plating appropriate dilutions on trypticase-soy-agar plate and counting the S.

Polymorphic forms of a hydrochloride salt of s 1- 9h-purinylamino propyl fluorophenylquinazolin-4 3h -one. Compound was reacted in accordance with the procedure described above for compound step D to provide compound For other diseases, including those involving the respiratory tract, e.

Compounds and pharmaceutical compositions suitable for use in the present invention include those wherein the active ingredient is administered in an effective amount to achieve its intended purpose. U, last updated on Jul.

Unless otherwise constrained by the definition prepqratyka the heterocyclic substituent, such heterocyclic groups can be optionally substituted with 1 to 5 substituents in some embodiments, 1, 2 or 3 substituentsselected from the group consisting of alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, aminocarbonyl, hydroxy, alkoxy, halogen, CF 3amino, a.i.vogeel amino, nitro, thiol, cyano, cycloalkyl, heterocyclyl, aryl, and heteroaryl.

Compound 38 was prepared using the general procedure described above with respect to compound 14, but 3-fluoroaniline was substituted for aniline in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure TFA deprotection was used in step C, and 2-aminobromopurine was substituted for 6-bromopurine in step D.

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Compound 70 was prepared using the general procedure described above with respect to compound 14, but 2,6-difluoroaniline was substituted for aniline in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure TFA deprotection was used in step C, and 2-aminobromopurine was substituted for 6-bromopurine in step D.

This application claims the benefit of International Application No. The reaction and compound are shown below. The resulting mixture was placed under a hydrogen atmosphere balloon pressure and allowed to stir at ambient temperature overnight. Another aspect of the present invention is to provide an article of manufacture for human pharmaceutical use comprising:.

S 1-aminoethyl fluoro phenylquinazolin-4 3H -one. In general, compounds of the present invention have the general structural formulae I or IIor a pharmaceutically acceptable salt thereof, or prodrug, or solvate thereof:.

Preparatyka organiczna vogel pdf download

First Office Action mailed Sep. In some embodiments, the dehydrating agent is DPP. Intermediate compound 11 was prepared using the method described above with respect to intermediate compound 10, but 2-aminobromopurine was used in place of 6-bromopurine. Resolution of the final product, an intermediate, or a starting material can be achieved by any suitable method known in the art. S -tert-butyl 1- 6-fluorooxophenyl-3,4- dihydroquinazolinyl ethyl carbamate.

Compound 45 was prepared using the general procedure described above with respect to compound 14, but tert-butoxycarbonylamino-phenyl-acetic acid 2,5-dioxo-pyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure TFA deprotection was used in step C, and 4-chloro-7H-pyrrolo[2,3-d]pyrimidine was substituted for 6-bromopurine in step D.

In some embodiments, step c comprises combining one or more reagents for the deprotection of amino protective groups. A mL, one-neck, round bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 2-aminomethylmethylphenyl-3H-quinazolinone 2.

Wydanie the viscosity of glaze as a function of temperature, using Vogel — Fulcher — Tammann. In various embodiments exhibiting increased potency relative to other compounds in accordance with the invention, R 8 is C alkyl, F, Cl, or CF 3. Superoxide generated by the neutrophils is measured by monitoring a change in absorbance upon reduction of cytochrome C by modification of the method described by Green et al. Compound 62 was prepared using the general procedure described above with respect to compound 61, but 2-aminobromopurine was substituted for 6-bromopurine in step D.

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A mL, three-neck, round bottomed flask equipped with a magnetic stirrer was charged with compound 4. Compound 44 is shown below. Principles and Practice of Oncology 4th ed.

Compound 20 was prepared using the general procedure described above with respect to compound 14, but 2,6-difluoroaniline was substituted for aniline in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, the alternate procedure TFA deprotection was used in step C, and 2-aminobromopurine was substituted for 6-bromopurine in step D. Superoxide is released by neutrophils in response to any of a variety of stimuli, including signals of infection, as a mechanism of cell killing.

Compound was prepared using the general procedure described above with respect to compound 14, but 2-amino-4,5-difluoro-benzoic acid was substituted for 2-aminomethyl-benzoic acid in step A, 2-tert-butoxycarbonylamino-propionic acid 2,5-dioxopyrrolidinyl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidinyl ester in step B, and the alternate procedure TFA deprotection was used in step C. For example, C 1 -C 8 alkyl is meant to include, but is not limited to methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, hexyl, isohexyl, and neohexyl.

In some embodiments, the amino protective group is BOC. The reaction mixture was concentrated in vacuo to a brown syrup. For a review of combinatorial chemistry and libraries created thereby, see Myers, Curr Opin Biotechnol, 8: In some embodiments, the purinyl group is has with 0, 1 or 2 substituents selected from the group consisting of methyl, ethyl, propyl, NH 2and N CH 3 2.

International Search Report mailed Apr.