Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.

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Introduction Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ].

Then, solvents of the different obtained extracts were evaporated and the dried residues were used to explore their cytotoxic effect.

Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against RD cell line by MTT assay. These plants are widely used in the Moroccan traditional folk medicine. The results of this study showed thus that Cotula cinerea essential oil and hexane extract showed significant cytotoxic effects against RD and Vero cell lines, respectively, and could be considered as novel source of antitumor agents. Phillips Cotula pterocarpa DC.

Hilliard Cotula loganii Hutch. Evaluation of the Cytotoxicity Before evaluating the antiproliferative activity, the cellular density of each species was determined using light microscopy. The obtained results raise then the possibility of a potential use of Cotula cinerea as a source of potent anticancer products.

View at Google Scholar F. Cancer is a complex disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ]. Cabrera Cotula microglossa DC.

TrekNature | Cotula cinerea Photo

Oils, Volatile Search for additional papers on this topic. The tentative global mechanism gathered probably all these actions which are thus supposed to provide the observed cytotoxic effect. In other projects Wikimedia Commons Wikispecies. Exploring alternative sources of new antitumor agents with specific targets is thus imperative and of great and crucial importance. Cotula is a genus of flowering plant in the sunflower family.


Voucher specimens of both plants were deposited in the herbarium of the Botany Department of this institution. Gymnogyne Steetz Peyrousea DC. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License.

The obtained results showed that the cytotoxicity differed according to the used extract with an efficient effect of Cotula cinerea extracts compared to Salvia verbenaca.

Cotula – Wikipedia

The activity of cotla essential oil is generally attributed and influenced by the major compounds. Cotula cinerea which is of the Asteraceae family is a xerophytic plant widely distributed in sandy and desert grounds [ 11 ]. Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed.

This study is expected thus to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further exploration on other types of cancer cell lines. These compounds could act cotkla or in a synergic manner.

Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against Vero cell line by MTT assay.

Lloyd has proposed that the five species from Australia and New Guinea are distinctive enough from the other species from the section Leptinella to be brought under a cinerra section with the proposed name Oligoleima type species C. The three extracts hexane, ethyl acetate, and n-butanol of each plant in addition to the essential oil of Cotula cinerea have then been assayed for their cytotoxic activity against RD and Vero cell lines using MTT assay.

References Publications referenced by this paper.

Flavonoids from Cotula cinerea Del

Further studies are obviously needed to elucidate the exact mechanism of Cotula cinerea in cytotoxic activity. Indeed, plants are rich sources of new compounds from which some secondary metabolites have been shown to possess anticancer properties [ 5 — 7 ].

The biological activity of C. Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc. The results are expressed as percentage of cytotoxicity versus the concentrations of the essential oil or extracts of both plants. The two tumor tested cell lines used in this study were RD Human Embryonal Rhabdomyosarcoma cancerous cell lines: Cotula is the largest genus found in the Southern Hemisphere of the tribe Anthemideae. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided corula original work is properly cited.


Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played [6] [7]. Articles with ‘species’ microformats Commons category link is on Wikidata Taxonbars with 20—24 taxon IDs Taxonomy articles created by Polbot. The hexane, ethyl acetate, and n -butanol extraction yields were, respectively, 1. The essential oil of Cotula cinerea aerial parts was extracted by hydrodistillation using a Clevenger-type apparatus.

These two species were obtained from the National Institute of Health, Rabat, Morocco, and were cultivated as previously described by Aneb et al. After 24 h incubation, cells were then treated with the essential oil of Cotula cinerea or its extracts hexane, ethyl acetate, and n dinerea in addition to those of Salvia verbenaca.

Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. For the town, see Cotula, Tennessee.

These corollas may be tubular, reduced or even absent. Chemical composition and Anticandidal properties of the essential oil isolated from aerial parts of Cotula Cinerea: The action and mechanism of Cotula ccinerea essential oil is very complex involving several targeting pathways as previously reported [ 5 ].

Cineeea vulgaris Levyns Cotula zeyheri Fenzl. Prolonged cancer treatment is generally costly to patients and complicates patient follow-up in hospital.