Chlorothiazide should be used cautiously in patients with renal disease resulting in severe renal impairment because the drug decreases the glomerular. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Diuril (Chlorothiazide). Chlorothiazide sodium for injection, USP is a diuretic and a vial containing: Chlorothiazide sodium equiva- . toxicity. Refer to the package insert for lithium.

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Patients using cardiovascular drugs concomitantly with apraclonidine should have their pulse and blood pressure monitored periodically.

However, patients taking antidiabetic agents should be monitored for changes in blood glucose control if such diuretics are added or deleted. Therefore, caution is advisable during concurrent use of pimozide knsert thiazide diuretics. Moderate Patients on antihypertensive agents receiving bortezomib treatment may require close monitoring of their padkage pressure and dosage adjustment of their medication.

Moderate Baclofen has been associated with hypotension.

Clozapine used concomitantly with the antihypertensive agents can increase the risk and severity of hypotension by potentiating the effect of the antihypertensive drug. Moderate Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents.

In addition, diuretics can increase urinary frequency, which may aggravate bladder symptoms. Moderate When canagliflozin is initiated in patients already receiving diuretics, symptomatic hypotension can occur.

Dilution Chlorothiazide – GlobalRPH

Intravenous use in infants and children has been limited and is not generally recommended. Moderate Secondary to alpha-blockade, iloperidone can produce vasodilation that may result in additive effects during concurrent use with antihypertensive agents.


Hypokalemia may cause cardiac arrhythmias and may also sensitize or exaggerate the response of the heart to the toxic effects of digitalis e.

Although any chloride deficit is generally mild and usually does not require specific treatment except under extraordinary circumstances as in liver disease or renal diseasechloride replacement may be required in the treatment of metabolic alkalosis.

Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction, rather than administration of salt, except in rare instances when the hyponatremia is life-threatening. Monitor baseline and periodic potassium concentrations during coadministration. If inserrt, dosage of the antihypertensive agents should be reduced.

However, in clinical trials with alprostadil intracavernous injection, anti-hypertensive agents had no apparent effect on the safety and efficacy of alprostadil. Moderate Citalopram causes dose-dependent QT interval prolongation. Polyethylene Glycol; Electrolytes; Ascorbic Acid: Moderate Thiazide diuretics may potentiate the hypotension seen with aldesleukin, IL 2. In general, use diuretics with caution in patients with hepatic disease since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Moderate Sympathomimetics can antagonize the effects of antihypertensives when administered concomitantly. Moderate Thiazide diuretics can cause hyperuricemia. Severe Hypokalemia or hypomagnesemia may occur with administration of potassium-depleting drugs such as loop diuretics and thiazide diuretics, increasing the potential for dofetilide-induced torsade de pointes. Generally, the reconstituted solution should be used immediately after reconstitution. Moderate Coadministration may lead to hypercalcemia because thiazides cause a decrease in renal tubular excretion of calcium as well as increase in distal tubular reabsorption.

According to the Packsge Criteria, diuretics are considered potentially inappropriate medications PIMs in geriatric patients and should be used with caution due to the potential for causing or exacerbating SIADH or hyponatremia; sodium inserrt should be closely monitored when starting or changing dosages of diuretics in older adults.


Discontinuation of citalopram should be considered in patients who develop symptomatic hyponatremia. Moderate Sulfonamides may cause photosensitization and may increase the photosensitizing effects of thiazide diuretics.

Thiazide-induced hyperbilirubinemia is greater in this patient population. Following intravenous use of chlorothiazide sodium, onset of the diuretic action occurs in 15 minutes and the maximal action in 30 minutes.

Akorn – Sodium DiurilĀ® (chlorothiazide sodium)

Orthostatic riuril signs should be monitored in patients receiving this combination who are susceptible to hypotension. Moderate Coadministration of thiazide diuretics and antineoplastic agents such as cyclophosphamide may result in reduced renal excretion of the antineoplastic agent and therefore increased myelosuppressive effects.

Moderate Fish oil supplements may cause isnert, dose-dependent reductions in systolic or diastolic blood pressure in untreated hypertensive patients. Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: Use caution with in-clinic dosing for erectile dysfunction ED and monitor for the effects on blood pressure.

Discontinuation of fluvoxamine should be considered in patients who develop symptomatic hyponatremia. Minor Due to additive hypotensive effects, patients receiving antihypertensive agents concurrently with trazodone may have excessive hypotension.

Moderate Alemtuzumab may cause hypotension.