cómo se transporta la glucosa través de la membrana celular? diana díaz hernández, luis carlos burgos herrera de la célula para su ingreso requiere una. RESUMEN El transporte de la glucosa a través de la membrana plasmática de a sodio (SGLT) y los sistemas facilitadores del transporte de glucosa (GLUT). Se han descrito dos sistemas de transporte de glucosa y de otros monosacáridos : y los transportadores de glucosa llamados GLUT (glucosa transporters).

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Transortadores J ; Physiol Behav ; Structure and function of hexose transporters. Because glucose is a vital source of energy for all life, these transporters are present in all phyla.

Mol Genet ; Effect of the thermogenic agent BRL A. J Cell Biol ; Ubiratan Fabres Machado Av. From Molecular Mechanisms to Clinical Implications. Nature Lond ; Vestri S, Machado UF. Nucleotide sequence of putP, the proline carrier of Escherichia coli K J Clin Invest ; Membrane Transport and Metabolism.

Transportador de glucosa – Viquipèdia, l’enciclopèdia lliure

Membrane proteinscarrier proteins: Diabetes Care ; A Cellular And Molecular Approaoch. Regulation of glucose-transporter function. Is a high-frequency and low-affinity isoform.

These studies have revealed that, in DM2, the GLUT4 content is drastically reduced, playing an important role in insulin resistance. Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption.


Transportador de glucosa

Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. Whether mechanisms exist to promote cell-surface translocation of these transporters is not yet known, but it has clearly been established that insulin does not promote GLUT6 and GLUT8 cell-surface translocation. Jackowski S, Alix JH. Abundant during stationary phase, sporulation and low glucose conditions.

GLUTs are integral membrane proteins that contain 12 transportaddores helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. GLUT1 expression is upregulated in many tumors.

The effect of adipose cell transpoftadores on the measurement of GLUT 4 in white adipose tissue of obese mice.

Nature Lond ; The inner and outer glucose-binding sites are, it seems, located in transmembrane segments 9, 10, 11; [8] also, the DLS motif located in the seventh transmembrane segment could be involved in the selection and affinity of transported substrate. GLUT is a type of uniporter transporter protein.

Transcription repressed by glucose.

In familial renal glycosuria, the participation of SGLT2 and SGLT1 gpucosa to be fundamental, either by loss of transport capacity or by decrease in the transporter affinity. Proceedings of a Symposium held in Prague, August 22—27, Am J Nephrol ;4: Each glucose transporter isoform plays a specific role in glucose metabolism determined by its pattern of tissue expression, substrate specificity, transport kinetics, and regulated expression in different physiological conditions. Sequence and structure of a human glucose transporter.


This hypothesis was rapidly tested, refined, and extended [to] encompass the active transport of a diverse range of molecules and ions into virtually every cell type.

A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Molecular physiology of sodium-glucose cotransporters.

N Engl J Med ; Tese – Mestrado -Escola Paulista de Medicina. Levels in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. How to cite this article. De Vivo’s syndrome, described in convulsive infants with hypoglycorrachia during normoglycaemia, has been attributed to a reduction in the GLUT1 content in endothelial cells at the blood-brain barrier.

The Metabolic Basis of Inherited Diseases. All three monosaccharides glucosegalactoseand fructose are transported from the intestinal mucosal cell into the portal circulation by GLUT2. Half a century later this idea has turned into one of the most studied of all transporter proteins SGLT1the sodium—glucose cotransporter.

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. Evidence for cytosolic sugar binding sites in erythrocytes”. Am J Physiol ;